Tiemessen C H, Bots R S, Peeters M F, Evers J L
Department of Obstetrics and Gynaecology, St. Elisabeth Hospital, Tilburg, The Netherlands.
Gynecol Obstet Invest. 1997;44(3):149-52. doi: 10.1159/000291508.
The aim of this randomized cross-over study was to determine whether direct intraperitoneal insemination (DIPI) is superior to intrauterine insemination (IUI) in hyperstimulated cycles. The treatment cycles were stimulated with either clomiphene citrate and human menopausal gonadotrophins, or buserelin and human menopausal gonadotrophins. 207 subfertile couples with a cervical factor, a male factor, a combined cervical and male factor, or an unexplained subfertility were randomly assigned to the first treatment cycle. IUI and DIPI were performed in alternate cycles to a maximum of 6 cycles per couple. Every treatment cycle was followed by a nontreatment cycle. The pregnancy rate per completed cycle was 24% for IUI and 16% for DIPI (p = 0.018), whereas the cumulative pregnancy rates for IUI and DIPI were 53 and 40%, respectively (p = 0.002). There were no significant differences between pregnancy rates for IUI and DIPI in the different categories of subfertility. We conclude that DIPI does not offer better pregnancy chances than IUI in superovulated cycles.
这项随机交叉研究的目的是确定在超促排卵周期中，直接腹腔内授精（DIPI）是否优于子宫内授精（IUI）。治疗周期采用枸橼酸氯米芬与人绝经期促性腺激素联合刺激，或布舍瑞林与人绝经期促性腺激素联合刺激。207对因宫颈因素、男性因素、宫颈和男性联合因素或不明原因不孕的不育夫妇被随机分配至第一个治疗周期。IUI和DIPI在交替周期进行，每对夫妇最多进行6个周期。每个治疗周期后紧接着一个非治疗周期。IUI每个完整周期的妊娠率为24%，DIPI为16%（p = 0.018），而IUI和DIPI的累积妊娠率分别为53%和40%（p = 0.002）。在不同类型的不育中，IUI和DIPI的妊娠率没有显著差异。我们得出结论，在超排卵周期中，DIPI并不比IUI提供更好的妊娠机会。
