Kent S J, Woodward A, Zhao A
Macfarlane Burnet Centre for Medical Research, Fairfield, Victoria, Australia.
J Infect Dis. 1997 Nov;176(5):1188-97. doi: 10.1086/514112.
Macaca nemestrina efficiently control acute human immunodeficiency virus type 1 (HIV-1) infection. The roles of helper (Th) and cytotoxic (CTL) T cells in controlling acute HIV-1 infection in both peripheral blood and lymph node mononuclear cells (PBMC and LNMC) were assessed in this model. Th and CTL responses to HIV-1 were detected within 2 weeks following HIV-1 infection, and CTL responses to HIV-1 antigens peaked at 4 weeks after infection (>100 HIV-specific CTL/10[6] PBMC), coincident with reductions of HIV-1 RNA and DNA levels in peripheral blood. HIV-1-specific Th and CTL were present in LNMC 6 weeks after infection. Although HIV-1 antibodies were detected 2 weeks after infection, maximal HIV-1 antibody responses were not generated until > 13 weeks after inoculation. Thus, T cell responses temporally correlate with control of HIV-1 in macaques. The induction of a brisk HIV-1-specific CTL response may have been facilitated by a persistent Th response.
食蟹猴能有效控制急性1型人类免疫缺陷病毒（HIV-1）感染。在该模型中评估了辅助性（Th）和细胞毒性（CTL）T细胞在控制外周血和淋巴结单核细胞（PBMC和LNMC）中急性HIV-1感染的作用。在HIV-1感染后2周内检测到对HIV-1的Th和CTL反应，对HIV-1抗原的CTL反应在感染后4周达到峰值（>100个HIV特异性CTL/10[6]PBMC），这与外周血中HIV-1 RNA和DNA水平的降低同时发生。感染6周后，LNMC中存在HIV-1特异性Th和CTL。虽然感染后2周检测到HIV-1抗体，但直到接种后>13周才产生最大的HIV-1抗体反应。因此，T细胞反应在时间上与猕猴体内HIV-1的控制相关。持续的Th反应可能促进了快速的HIV-1特异性CTL反应的诱导。
