Hata K, Hata T
Department of Obstetrics and Gynecology, Shimane Medical University, Izumo, Japan.
J Ultrasound Med. 1997 Nov;16(11):737-41. doi: 10.7863/jum.1997.16.11.737.
Our objective was to compare ophthalmic artery flow velocity waveforms in unilateral oophorectomized patients not on hormone replacement therapy with findings in bilateral oophorectomized patients on hormone replacement therapy. Ten patients who underwent hysterectomy and unilateral oophorectomy and 10 women treated by hysterectomy and bilateral oophorectomy were studied using color and pulsed Doppler ultrasonography 1 day before and on days 7 and 28 after surgery. Serum estradiol levels were measured serially. Bilateral oophorectomy patients were given hormone replacement therapy (conjugated estrogen, 0.625 mg/day, and medroxyprogesterone acetate, 2.5 mg/day) orally starting on day 8 after surgery. The pulsatility index values of the ophthalmic artery in unilateral oophorectomy patients were 1.93 +/- 0.41, 2.10 +/- 0.26, and 1.68 +/- 0.27 for 1 day before and on days 7 and 28 after surgery, respectively. The pulsatility index values of the ophthalmic artery in bilateral oophorectomy patients were 1.99 +/- 0.39, 2.17 +/- 0.47, and 1.75 +/- 0.32 for 1 day before and on days 7 and 28 after surgery, respectively. No significant differences were found between pulsatility index values in the unilateral and bilateral oophorectomy patients in each time period. The pulsatility index values on day 28 decreased significantly compared with the findings on day 7 in both groups (P < 0.05). The serum estradiol levels were significantly reduced from 1 day before to day 7 day after surgery and were significantly elevated by day 28 after surgery (P < 0.05) in both groups of patients. No significant differences were found between the serum estradiol levels in the unilateral and bilateral oophorectomy patients in each time period. Vascular tone in the ophthalmic artery seems to change according to serum estradiol levels, a finding that may help explain some of the beneficial effects of hormone replacement therapy for bilateral oophorectomized patients.
我们的目的是比较未接受激素替代疗法的单侧卵巢切除患者与接受激素替代疗法的双侧卵巢切除患者的眼动脉血流速度波形。对10例行子宫切除术和单侧卵巢切除术的患者以及10例行子宫切除术和双侧卵巢切除术的女性，在术前1天以及术后第7天和第28天使用彩色和脉冲多普勒超声进行研究。连续测量血清雌二醇水平。双侧卵巢切除患者在术后第8天开始口服激素替代疗法（结合雌激素，0.625mg/天，醋酸甲羟孕酮，2.5mg/天）。单侧卵巢切除患者术后第1天、第7天和第28天眼动脉的搏动指数值分别为1.93±0.41、2.10±0.26和1.68±0.27。双侧卵巢切除患者术后第1天、第7天和第28天眼动脉的搏动指数值分别为1.99±0.39、2.17±0.47和1.75±0.32。在每个时间段，单侧和双侧卵巢切除患者的搏动指数值之间未发现显著差异。两组患者术后第28天的搏动指数值与术后第7天相比均显著降低（P<0.05）。两组患者血清雌二醇水平从术前1天至术后第7天显著降低，术后第28天显著升高（P<0.05）。在每个时间段，单侧和双侧卵巢切除患者的血清雌二醇水平之间未发现显著差异。眼动脉的血管张力似乎根据血清雌二醇水平而变化，这一发现可能有助于解释激素替代疗法对双侧卵巢切除患者的一些有益作用。
