Odagiri T
Department of Microbiology, Kanazawa Medical University.
Nihon Rinsho. 1997 Oct;55(10):2547-54.
The genome of influenza A viruses consists of eight negative-strand RNA segments. These segments contain the untranslated regions (UTRs), ranging from 20 to 61 nucleotides, at their 3' and 5' ends. The UTRs are composed of the highly conserved terminal nucleotides and the segment-specific nonconserved nucleotides located adjacent the open reading frame of the viral RNAs. Utilizing the virus-like model RNAs, whose nonconserved UTRs were mutated, deleted or replaced with those of other segments, the unique features of the nonconserved UTRs have been elucidated in the steps of transcription, translation, replication and RNA packaging into virus particles. Here I summarize current understanding of the functions of the segment-specific nonconserved UTRs of virus RNA.
甲型流感病毒的基因组由八个负链RNA片段组成。这些片段在其3'和5'末端含有20至61个核苷酸的非翻译区（UTR）。UTR由高度保守的末端核苷酸和位于病毒RNA开放阅读框附近的片段特异性非保守核苷酸组成。利用非保守UTR发生突变、缺失或被其他片段的UTR取代的病毒样模型RNA，已在转录、翻译、复制和RNA包装入病毒颗粒的步骤中阐明了非保守UTR的独特特征。在此，我总结了目前对病毒RNA片段特异性非保守UTR功能的理解。
