Suzuki Y
Department of Biochemistry, University of Shizuoka School of Pharmaceutical Sciences.
Nihon Rinsho. 1997 Oct;55(10):2640-7.
Host-range of influenza viruses are established by many factors in nature such as the quantitative, qualitative aspects of the viral receptor, the permissive and non permissive states of host-cell condition, and also the antibody and inhibitor pressure present in the host. Influenza virus hemagglutinin recognizes specific sialyl-sugar chains of the host cell membranes. In this paper, the structure and function of sialyl-sugar chains as influenza virus receptors are described in relation to the variation of influenza viruses and the molecular evolution of influenza virus hemagglutinin.
流感病毒的宿主范围由自然界中的许多因素决定，如病毒受体的数量和质量方面、宿主细胞状态的允许和非允许状态，以及宿主中存在的抗体和抑制剂压力。流感病毒血凝素识别宿主细胞膜上特定的唾液酸糖链。本文结合流感病毒的变异和流感病毒血凝素的分子进化，描述了作为流感病毒受体的唾液酸糖链的结构和功能。
