Laidler P, Lityńska A
Institute of Medical Biochemistry, Collegium Medicum, Jagiellonian University, Cracow, Poland.
Acta Biochim Pol. 1997;44(2):343-57.
Metastasis accounts for most of deaths caused by cancer. The increasing body of evidence suggests that changes in N-glycosylation of tumor cell proteins such as increased branching, increased sialylation, polysialylation, decreased fucosylation, enhanced formation of Lewis X and sialyl Lewis X antigens are among important factors determining metastatic potential of tumor cell. Most of the adhesion proteins, e.g., integrins, members of immunoglobulin superfamily, and cadherins are heavily N-glycosylated. The other proteins involved in adhesion, like galectins and type-C selectins, recognize N-glycans as a part of their specific ligands. In this review we focus on recent reports concerning the contribution of N-glycosylation of tumor cell adhesion molecules and some selected membrane proteins in the tumor invasion and metastasis.
转移是癌症致死的主要原因。越来越多的证据表明，肿瘤细胞蛋白质的N-糖基化变化，如分支增加、唾液酸化增加、多唾液酸化、岩藻糖基化减少、Lewis X和唾液酸化Lewis X抗原形成增强等，是决定肿瘤细胞转移潜能的重要因素。大多数黏附蛋白，如整合素、免疫球蛋白超家族成员和钙黏蛋白，都有大量的N-糖基化。其他参与黏附的蛋白质，如半乳糖凝集素和C型选择素，将N-聚糖识别为其特定配体的一部分。在本综述中，我们重点关注了关于肿瘤细胞黏附分子和一些选定膜蛋白的N-糖基化在肿瘤侵袭和转移中的作用的最新报道。
