Beckmann C R
Department of Obstetrics and Gynecology, University of Missouri at Kansas City, School of Medicine, Truman Medical Center West 64108, USA.
Curr Opin Obstet Gynecol. 1997 Oct;9(5):295-9.
The prospect that Alzheimer's disease is caused by or related to estrogen deficiency, and treatable or even preventable by estrogen replacement therapy, is alluring. At present, evidence that Alzheimer's disease is an estrogen deficiency disease is lacking. However, there is much evidence that beneficial effects of estrogen replacement therapy on the areas of the brain associated with Alzheimer's disease may prevent or slow the progress of Alzheimer's disease or the expression of Alzheimer's disease symptoms. Given the proven value of estrogen replacement therapy for most women for other indications, this probable additional benefit is welcome. Further research is needed.
阿尔茨海默病由雌激素缺乏引起或与之相关，且可通过雌激素替代疗法进行治疗甚至预防，这一前景颇具吸引力。目前，尚无证据表明阿尔茨海默病是一种雌激素缺乏疾病。然而，有大量证据表明，雌激素替代疗法对与阿尔茨海默病相关的脑区具有有益作用，可能会预防或减缓阿尔茨海默病的进展或症状表现。鉴于雌激素替代疗法对大多数有其他适应症的女性已证实的价值，这种可能的额外益处是值得欢迎的。还需要进一步的研究。
