Monsees T K, Schill W B, Miska W
Center of Dermatology and Andrology, Justus Liebig University, Giessen, Germany.
Adv Exp Med Biol. 1997;424:111-23. doi: 10.1007/978-1-4615-5913-9_20.
Peritubular cells, Sertoli cells, and germ cells of the seminiferous tubule synthesize and secrete several proteases and protease inhibitors. Experimental evidence suggests that the complex network of proteolytic enzyme activity and their regulation by protease inhibitors play an important role in male reproduction. Interaction between protease and protease inhibitors seems to play an important role in remodeling and restructuring of the seminiferous tubule during spermatogenesis. Controlled proteolytic activity is also involved in the migration of germ cells from the basal compartment to the lumen of the seminiferous epithelium, and in the release of spermatids during spermiation. The recently reported occurrence of Sertoli cell membrane-associated proteases indicate the possible involvement of regulatory peptide systems within the testis. This view is supported by the detection of all components of one of these paracrine systems, the kallikrein-kinin system, in cells of the seminiferous tubule.
生精小管的周细胞、支持细胞和生殖细胞合成并分泌多种蛋白酶和蛋白酶抑制剂。实验证据表明，蛋白水解酶活性及其受蛋白酶抑制剂调节的复杂网络在雄性生殖中起重要作用。蛋白酶与蛋白酶抑制剂之间的相互作用似乎在精子发生过程中生精小管的重塑和重构中起重要作用。受控的蛋白水解活性还参与生殖细胞从基部区域向生精上皮管腔的迁移，以及在精子释放过程中精子细胞的释放。最近报道的支持细胞膜相关蛋白酶的出现表明睾丸内调节肽系统可能参与其中。生精小管细胞中检测到这些旁分泌系统之一即激肽释放酶 - 激肽系统的所有成分，支持了这一观点。
