Doty R L
Smell and Taste Center, University of Pennsylvania Medical Center, Philadelphia 19104, USA.
Chem Senses. 1997 Oct;22(5):565-86. doi: 10.1093/chemse/22.5.565.
This paper, presented in part as an invited lecture on the occasion of Professor E.P. Köster's retirement from Utrecht University, summarizes a large body of human studies performed at the University of Pennsylvania Smell and Taste Center during the last 17 years. Details of the development of standardized olfactory tests are provided, including their validation and application in a wide variety of clinical and laboratory settings. Included are studies related to transduction mechanisms in olfactory coding and factors that adversely influence olfactory function (e.g. age, gender, smoking, exposure to environmental chemicals, numerous diseases). A brief discussion of the strengths and weaknesses of the olfactory vector hypothesis for neurodegenerative diseases is also presented.
本文部分内容是在E.P. 科斯特教授从乌得勒支大学退休之际作为特邀讲座发表的，总结了宾夕法尼亚大学嗅觉与味觉研究中心在过去17年里进行的大量人体研究。文中提供了标准化嗅觉测试的开发细节，包括其验证过程以及在各种临床和实验室环境中的应用。还包括与嗅觉编码中的转导机制以及对嗅觉功能产生不利影响的因素（如年龄、性别、吸烟、接触环境化学物质、多种疾病）相关的研究。此外，还简要讨论了神经退行性疾病嗅觉载体假说的优缺点。
