Laburn H P, Mitchell D
Department of Physiology, University of the Witwatersrand Medical School, Parktown, South Africa.
J Basic Clin Physiol Pharmacol. 1997;8(1-2):1-11. doi: 10.1515/jbcpp.1997.8.1-2.1.
We administered extracts of the horn of the African Black rhinoceros intragastrically to 7 rabbits, at the same time as injecting bacterial lipopolysaccharide (LPS) intravenously into the rabbits to produce fever. At a dose of horn (50 mg/kg) similar to that allegedly used to reduce human fever, and at ten times that dose, the fever response to LPS was not significantly different (P > 0.05, t-test) to the response to LPS injection when boiled water was administered instead of horn extract. The known antipyretic indomethacin, however, at a dose of 10 mg/kg significantly reduced the response to LPS.
我们给7只兔子灌胃非洲黑犀牛角提取物，同时给这些兔子静脉注射细菌脂多糖（LPS）以引起发热。在与据称用于降低人体发热的剂量（50毫克/千克）相同以及该剂量的10倍时，对LPS的发热反应与给予开水而非犀牛角提取物时对LPS注射的反应相比，没有显著差异（P>0.05，t检验）。然而，已知的退烧药吲哚美辛，以10毫克/千克的剂量显著降低了对LPS的反应。
