Breul J, Tief G, Hartung R
Urologische Klinik und Poliklinik der Technischen Universität M-unchen, Klinikum rechts der Isar Ismaningerstr. 22, Munich D-81675, Germany.
Eur J Med Res. 1996 Apr 18;1(7):339-42.
Results of cytotoxic chemotherapy in metastatic renal cell carcinoma are not impressive. Remission rates range between 0 and 20%. One of the substances which show a marginal effect is 5-fluorouracil (5-FU). The cytotoxicity of 5-FU can be modulated by combination with folinic acid as shown in various cell lines and clinical trials. We were interested to see whether such a biomodulation also occurs in renal cell cancer. The antiproliferative effect of 5-fluorouracil on two human cell lines of RCC and its potentiation by folinic acid was investigated in a monolayer proliferation assay. It could be shown that folinic acid enhanced the cytotoxic potential of 5-FU 6-8-fold. Our results indicate that the combination of these two drugs in the treatment of metastatic renal cell cancer might lead to better response rates.
细胞毒性化疗在转移性肾细胞癌中的效果并不显著。缓解率在0%至20%之间。5-氟尿嘧啶（5-FU）是显示出轻微效果的物质之一。如在各种细胞系和临床试验中所示，5-FU的细胞毒性可通过与亚叶酸联合使用来调节。我们感兴趣的是这种生物调节在肾细胞癌中是否也会发生。在单层增殖试验中研究了5-氟尿嘧啶对两种人肾细胞癌细胞系的抗增殖作用及其被亚叶酸增强的作用。结果表明亚叶酸可将5-FU的细胞毒性潜力提高6至8倍。我们的结果表明，这两种药物联合用于治疗转移性肾细胞癌可能会带来更高的缓解率。
