阿尔茨海默病：风险与防护

Alzheimer's disease: risk and protection.

作者信息

Jorm A F

机构信息

National Health and Medical Research Centre Psychiatric Epidemiology Research Centre, Australian National University, Canberra, ACT.

出版信息

Med J Aust. 1997 Oct 20;167(8):443-6. doi: 10.5694/j.1326-5377.1997.tb126660.x.

DOI:10.5694/j.1326-5377.1997.tb126660.x

PMID:9364167

Abstract

Only four risk factors for Alzheimer's disease can be regarded as confirmed--old age, family history of dementia, apo-E genotype and Down syndrome. Other disputed risk factors with some supporting evidence include ethnic group, head trauma and aluminium in drinking water. Possible protection factors, such as anti-inflammatory drugs, oestrogen replacement therapy and a high education level, are of great interest because they suggest possible preventive action.

摘要

只有四种阿尔茨海默病的风险因素可被视为已得到确认——高龄、痴呆家族史、载脂蛋白E基因型和唐氏综合征。其他有一些支持证据但存在争议的风险因素包括种族、头部外伤和饮用水中的铝。一些可能的保护因素，如抗炎药物、雌激素替代疗法和高教育水平，因其提示了可能的预防措施而备受关注。