同时摄入γ-羟基丁酸（GHB）和乙醇后从近乎昏迷状态突然苏醒。
A sudden awakening from a near coma after combined intake of gamma-hydroxybutyric acid (GHB) and ethanol.
作者信息
Louagie H K, Verstraete A G, De Soete C J, Baetens D G, Calle P A
机构信息
Department of Clinical Biology, University Hospital, Ghent, Belgium.
出版信息
J Toxicol Clin Toxicol. 1997;35(6):591-4. doi: 10.3109/15563659709001237.
OBJECTIVE
A case of a sudden awakening from a near coma after combined intake or gamma-hydroxybutyric acid (GHB) (125 micrograms/mL), ethanol (134 mg/dL), and cannabinoids is described.
METHODS
GHB was determined by gas chromatography-mass spectrometry after acetonitrile precipitation and derivation with N-methyl-N-trimethylsilyltrifluoroacetamide, using valproic acid as the internal standard.
CONCLUSION
The described case illustrates the consequences of GHB overdose. GHB overdose should be considered in every case of unexplained sudden coma, i.e., without any evidence of head injury, intake of coma-inducing drugs, or increasing intracranial pressure. GHB overdose will be missed by routine toxicological screening.
目的
描述一例在联合摄入γ-羟基丁酸（GHB，125微克/毫升）、乙醇（134毫克/分升）和大麻素后从接近昏迷状态突然苏醒的病例。
方法
以丙戊酸为内标，采用乙腈沉淀并用N-甲基-N-三甲基硅烷基三氟乙酰胺衍生化后，通过气相色谱-质谱法测定GHB。
结论
所述病例说明了GHB过量的后果。在每例不明原因的突然昏迷病例中，即无任何头部受伤、摄入致昏迷药物或颅内压升高证据的情况下，均应考虑GHB过量。常规毒理学筛查会遗漏GHB过量情况。
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