前列腺癌的化学预防：前列腺癌预防试验
Chemoprevention of prostate cancer: the Prostate Cancer Prevention Trial.
作者信息
Thompson I M, Coltman C A, Crowley J
机构信息
Department of Surgery, Brooke Army Medical Center, San Antonio, Texas 78234-6200, USA.
出版信息
Prostate. 1997 Nov 1;33(3):217-21. doi: 10.1002/(sici)1097-0045(19971101)33:3<217::aid-pros11>3.0.co;2-n.
BACKGROUND
A variety of innovative approaches to the prevention of prostate cancer are now available, including selenium, alpha tocopherol, dietary interventions, and vitamin D. Perhaps the most promising opportunity is based upon considerable evidence that cumulative androgen exposure of the prostate contributes to the age-related risk of prostate cancer.
METHODS
The Prostate Cancer Prevention Trial has completed randomization of over 18,000 healthy men to either finasteride or placebo.
CONCLUSIONS
While the primary objective of this study is to determine whether finasteride can reduce the period prevalence of prostate cancer over a 7-year period, the biologic and data resources of this study will provide multiple opportunities to better understand this most common cancer in U.S. men.
背景
目前有多种预防前列腺癌的创新方法，包括硒、α-生育酚、饮食干预和维生素D。或许最有前景的机会是基于大量证据，即前列腺的累积雄激素暴露会增加与年龄相关的前列腺癌风险。
方法
前列腺癌预防试验已完成对18000多名健康男性进行非那雄胺或安慰剂的随机分组。
结论
虽然本研究的主要目的是确定非那雄胺能否在7年内降低前列腺癌的期间患病率，但本研究的生物学和数据资源将提供多个机会，以更好地了解美国男性中这种最常见的癌症。
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