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[在多次接种脊髓灰质炎活疫苗的人群中发生轻度脊髓灰质炎脊髓型的可能性]

[Possibility of occurrence of mild spinal forms of poliomyelitis in subjects immunized repeatedly with live poliomyelitis vaccine].

作者信息

Modestova N V, Dvoskina B Ia, Nedel'ko N P, Astakhova A G, Zlobin V I

出版信息

Vopr Virusol. 1976 Mar-Apr(2):154-8.

PMID:936571
Abstract

The results of clinical, epidemiological, serological and virological examinations of patients with mild spinal forms of poliomyelitis occurring under conditions of mass immunization with oral live poliomyelitis vaccine are presented. The etiological role of poliomyelitis virus types I and III in these diseases has been established. It has been shown that multiple vaccination does not always prevent diseases but in these cases they are milder. Serological examination of patients and normal subjects suggests inadequacy of seroconversion to poliomyelitis viruses under conditions of mass vaccination of the population against poliomyelitis.

摘要

本文介绍了在口服脊髓灰质炎活疫苗大规模免疫接种情况下发生的轻度脊髓灰质炎患者的临床、流行病学、血清学和病毒学检查结果。已确定I型和III型脊髓灰质炎病毒在这些疾病中的病因作用。结果表明,多次接种并不总能预防疾病,但在这些情况下疾病症状较轻。对患者和正常受试者的血清学检查表明,在人群大规模接种脊髓灰质炎疫苗的情况下,针对脊髓灰质炎病毒的血清转化并不充分。

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