Sorokin A M, Lushnikov A A, Kol'tsov V D
Vopr Virusol. 1976 Mar-Apr(2):206-11.
Dibazole and vitamin B12 reduced production of hemagglutinin by influenza A (PR8 and WSN strain) and B-1/73 (Yamagata strain) viruses in chick embryos when inoculated at various intervals after infection. The drugs stimulated interferon production in serum and by blood leukocytes, showing also some protective effect in influenza infection in mice. The necessity of further study of relationships between the chemotherapeutic activity of drugs and their capacity to stimulate nonspecific resistance to infection is emphasized.
感染后不同时间接种时,地巴唑和维生素B12可降低甲型流感病毒(PR8和WSN株)及乙型流感病毒B-1/73(山形株)在鸡胚中血凝素的产生。这些药物可刺激血清及血液白细胞产生干扰素,对小鼠流感感染也有一定保护作用。强调了进一步研究药物化疗活性与其刺激机体对感染的非特异性抵抗力之间关系的必要性。