Lu Y J, Birdsall S, Osin P, Gusterson B, Shipley J
Section of Cell Biology and Experimental Pathology, Haddow Laboratories, Sutton Surrey, United Kingdom.
Genes Chromosomes Cancer. 1997 Nov;20(3):275-81.
Phyllodes tumors are rare neoplasms of the breast. Although they contain both epithelial and stromal components they are considered to be stromally derived lesions. The chromosomal copy number changes were determined in 19 well characterized samples from 18 patients using comparative genomic hybridization. Most chromosomes were involved and generally the gains and losses were similar to those found in breast cancer with the exception that the phyllodes tumors showed no evidence of genomic amplification. The one recurrent sample analyzed had the same imbalances as the original tumor. Frequent changes were gain of 1q (7/18) and loss of 3p (6/18), followed by gain of 7q (4/18) and loss of 6q (4/18) and 3q (3/18). Gain of 1q material was significantly associated with histologically defined stromal overgrowth (P = 0.011). In addition, all the cases with gain of 1q material, without 1p gain, had a clinical history of recurrence. Only one case without 1q gain had a recurrence and this had loss of the X chromosome as the sole abnormality. Increased copy number of 1q material in the phyllodes tumors studied, in one case restricted to 1q24-32, was associated with recurrence (P = 0.00365) and might therefore be considered as an indicator of local aggressiveness requiring more radical treatment.
叶状肿瘤是一种罕见的乳腺肿瘤。尽管它们包含上皮和间质成分，但被认为是起源于间质的病变。使用比较基因组杂交技术，对18例患者的19个特征明确的样本进行了染色体拷贝数变化测定。大多数染色体都有涉及，总体上，其增减情况与乳腺癌相似，但叶状肿瘤没有基因组扩增的证据。分析的一个复发样本与原始肿瘤具有相同的失衡情况。常见的变化包括1q增益（7/18）和3p缺失（6/18），其次是7q增益（4/18）、6q缺失（4/18）和3q缺失（3/18）。1q物质的增益与组织学定义的间质过度生长显著相关（P = 0.011）。此外，所有有1q物质增益且无1p增益的病例都有复发的临床病史。只有一例无1q增益的病例出现复发，且唯一的异常是X染色体缺失。在所研究的叶状肿瘤中，1q物质的拷贝数增加，在一例中局限于1q24 - 32，与复发相关（P = 0.00365），因此可能被视为需要更积极治疗的局部侵袭性指标。
