Lee Jiyun, Wang Jianzhou, Torbenson Michael, Lu You, Liu Qiong Z, Li Shibo
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Cancer Genet Cytogenet. 2010 Jan 15;196(2):179-83. doi: 10.1016/j.cancergencyto.2009.09.005.
We report oligo-array comparative genomic hybridization findings in a case of malignant phyllodes tumor of the breast. In addition to gains of 1q and 5p, and losses of 10p and 13q14 approximately q22, this tumor had also losses of two regions to which tumor suppressor genes are mapped: 1p36 (SDHB) and 17q11.2 (NF1). Both genes are associated with hereditary cancer syndromes, including gastrointestinal stromal tumors. Whether these two genes played a role in the development or progression of this phyllodes tumor of the breast with a sarcomatous stromal component warrants further investigation of similar cases.
我们报告了1例乳腺恶性叶状肿瘤的寡核苷酸阵列比较基因组杂交结果。除了1q和5p扩增以及10p和13q14至q22缺失外，该肿瘤还存在两个与肿瘤抑制基因相关区域的缺失：1p36（SDHB）和17q11.2（NF1）。这两个基因均与遗传性癌症综合征相关，包括胃肠道间质瘤。这两个基因是否在该伴有肉瘤样间质成分的乳腺叶状肿瘤的发生或进展中发挥作用，有待对类似病例进行进一步研究。
