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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Gorrod J W, Temple D J

Xenobiotica. 1976 May;6(5):265-74. doi: 10.3109/00498257609151638.

The metabolism of N-methylcarbazole has been studied in several mammalian species, both in vivo and in vitro. 2. An important metabolite after incubation of N-methylcarbazole with liver microsomes in vitro was identified as N-hydroxymethylcarbazole. 3. This metabolite was also found as a conjugate (probably the O-glucuronide) in the urine of some species. 4. N-Hydroxymethylcarbazole decomposed spontaneously in solution at pH 7-4 to formaldehyde and carbazole; this breakdown was enhanced by incubation with liver microsomes from several species, especially the guinea-pig. 5. The role of N-methyl hydroxylation, compared with N-oxidation, in the mechanism of N-dealkylation of non-basic N-methyl compounds is discussed.

已在多种哺乳动物体内和体外研究了N-甲基咔唑的代谢情况。2. 体外将N-甲基咔唑与肝微粒体孵育后，一种重要的代谢产物被鉴定为N-羟甲基咔唑。3. 在某些物种的尿液中也发现这种代谢产物是以结合物形式（可能是O-葡萄糖醛酸苷）存在。4. N-羟甲基咔唑在pH 7 - 4的溶液中会自发分解为甲醛和咔唑；与几种物种（尤其是豚鼠）的肝微粒体一起孵育可增强这种分解。5. 讨论了与N-氧化相比，N-甲基羟基化在非碱性N-甲基化合物N-脱烷基化机制中的作用。

Gorrod J W, Temple D J

Xenobiotica. 1976 May;6(5):265-74. doi: 10.3109/00498257609151638.

The metabolism of N-methylcarbazole has been studied in several mammalian species, both in vivo and in vitro. 2. An important metabolite after incubation of N-methylcarbazole with liver microsomes in vitro was identified as N-hydroxymethylcarbazole. 3. This metabolite was also found as a conjugate (probably the O-glucuronide) in the urine of some species. 4. N-Hydroxymethylcarbazole decomposed spontaneously in solution at pH 7-4 to formaldehyde and carbazole; this breakdown was enhanced by incubation with liver microsomes from several species, especially the guinea-pig. 5. The role of N-methyl hydroxylation, compared with N-oxidation, in the mechanism of N-dealkylation of non-basic N-methyl compounds is discussed.

已在多种哺乳动物体内和体外研究了N-甲基咔唑的代谢情况。2. 体外将N-甲基咔唑与肝微粒体孵育后，一种重要的代谢产物被鉴定为N-羟甲基咔唑。3. 在某些物种的尿液中也发现这种代谢产物是以结合物形式（可能是O-葡萄糖醛酸苷）存在。4. N-羟甲基咔唑在pH 7 - 4的溶液中会自发分解为甲醛和咔唑；与几种物种（尤其是豚鼠）的肝微粒体一起孵育可增强这种分解。5. 讨论了与N-氧化相比，N-甲基羟基化在非碱性N-甲基化合物N-脱烷基化机制中的作用。