Tsai H, Bobek L A
Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, 14214, USA.
Biochim Biophys Acta. 1997 Oct 20;1336(3):367-9. doi: 10.1016/s0304-4165(97)00076-7.
Human salivary histatins (Hsns) have been known to be potent antifungal agents against Candida albicans for more than a decade. Here, we report that Hsns are also effective in killing another medically important opportunistic fungal pathogen, Cryptococcus neoformans, which has become a new threat among the immunocompromised patients, especially AIDS patients. In fact, the cidal activity of Hsn-5 against C. neoformans is as high as that against C. albicans.
十多年来，人们一直知道人类唾液组蛋白（Hsns）是对抗白色念珠菌的强效抗真菌剂。在此，我们报告Hsns对另一种医学上重要的机会性真菌病原体新型隐球菌也有杀灭作用，新型隐球菌已成为免疫功能低下患者尤其是艾滋病患者中的新威胁。事实上，Hsn-5对新型隐球菌的杀菌活性与对白色念珠菌的杀菌活性一样高。
