遗传性孤立性生长激素缺乏症的磁共振成像表现
MR findings in hereditary isolated growth hormone deficiency.
作者信息
Kornreich L, Horev G, Lazar L, Josefsberg Z, Pertzelan A
机构信息
Department of Imaging, Schneider Children's Medical Center of Israel, Petah Tiqva and Sackler Faculty of Medicine, Tel Aviv University.
出版信息
AJNR Am J Neuroradiol. 1997 Oct;18(9):1743-7.
PURPOSE
To describe the MR characteristics by which patients with hereditary isolated growth hormone deficiency (GHD) can be distinguished from patients with other types of GHD.
METHODS
A total of 51 patients with GHD were examined prospectively with MR imaging. On the basis of familial occurrence of GHD and genetic analysis, 10 patients met the criteria for hereditary deficiency. In each case, the height of the pituitary gland, the presence and location of the posterior neurohypophysis, and the completeness of the stalk were recorded. The findings in the hereditary group were compared with those in the rest of the patients.
RESULTS
In all 10 patients with hereditary GHD, the adenohypophysis, the neurohypophysis, and the stalk were normal. Of the other 41 patients, the height of the gland was normal in three (7%), the neurohypophysis was abnormal in all, and the stalk was truncated in all but two patients (95%).
CONCLUSIONS
The subgroup of patients with hereditary GHD exhibited an anatomically normal pituitary-hypothalamic region. This is in contrast to the majority of patients with idiopathic GHD. MR imaging can contribute to the classification of patients with GHD.
目的
描述可用于区分遗传性孤立性生长激素缺乏症（GHD）患者与其他类型GHD患者的磁共振成像（MR）特征。
方法
对51例GHD患者进行了前瞻性MR成像检查。根据GHD的家族发病情况和基因分析，10例患者符合遗传性缺乏的标准。在每种情况下，记录垂体的高度、神经垂体的存在和位置以及垂体柄的完整性。将遗传性组的结果与其他患者的结果进行比较。
结果
在所有10例遗传性GHD患者中，腺垂体、神经垂体和垂体柄均正常。在其他41例患者中，3例（7%）垂体高度正常，所有患者神经垂体均异常，除2例患者外所有患者垂体柄均中断（95%）。
结论
遗传性GHD患者亚组表现出解剖结构正常的垂体-下丘脑区域。这与大多数特发性GHD患者相反。MR成像有助于GHD患者的分类。
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