Exner B G, Groninger J H, Ildstad S T
Allegheny University of the Health Sciences, Institute for Cellular Therapeutics, Philadelphia, Pennsylvania, USA.
Stem Cells. 1997;15 Suppl 1:171-5; discussion 175-6. doi: 10.1002/stem.5530150822.
A variety of clinical and experimental reports have shown the interdependence between bone marrow and autoimmune diseases. Autoimmune diseases can be transferred as well as cured by bone marrow transplantation (BMT). The widespread application of this therapeutic approach is limited today by the morbidity and mortality associated with BMT, including failure of engraftment, graft-versus-host disease (GVHD) and the toxicity from lethal conditioning approaches. Mixed chimerism (with the advantage of superior immunocompetence of the host and a relative protection against GVHD) can be achieved with incomplete ablation conditioning regimens. BMT may provide a potential strategy to treat those autoimmune diseases for which today only symptomatic treatment is available.
各种临床和实验报告表明了骨髓与自身免疫性疾病之间的相互依存关系。自身免疫性疾病可通过骨髓移植（BMT）进行转移和治愈。如今，这种治疗方法的广泛应用受到与BMT相关的发病率和死亡率的限制，包括植入失败、移植物抗宿主病（GVHD）以及致死性预处理方法的毒性。采用不完全清除预处理方案可实现混合嵌合体（具有宿主免疫能力优越以及相对预防GVHD的优势）。对于那些目前只有对症治疗的自身免疫性疾病，BMT可能提供一种潜在的治疗策略。
