Maser E, Oppermann U C
Department of Pharmacology and Toxicology, Philipps-University of Marburg, School of Medicine, Germany.
Eur J Biochem. 1997 Oct 15;249(2):365-9. doi: 10.1111/j.1432-1033.1997.00365.x.
Carbonyl reduction is a significant step in the biotransformation leading to the elimination, of endogenous and exogenous aldehydes, ketones and quinones. This reaction is mediated by members of the aldo-keto reductase and short-chain dehydrogenase/reductase (SDR) superfamilies. The essential role of these enzymes in protecting organisms from damage by the accumulation of toxic carbonyl compounds is generally accepted, although their physiological roles are not always clear. Recently, the SDR enzyme 11beta-hydroxysteroid dehydrogenase-1 has been identified to perform an important role in the detoxification of non-steroidal carbonyl compounds, in addition to metabolising its physiological glucocorticoid substrates. This review summarises the current knowledge of type-1 11beta-hydroxysteroid dehydrogenase and discusses possible substrate/inhibitor interactions. They might impair either the physiological function of glucocorticoids or the detoxification of non-steroid carbonyl compounds.
羰基还原是生物转化过程中的一个重要步骤，可导致内源性和外源性醛、酮及醌类物质的消除。该反应由醛酮还原酶和短链脱氢酶/还原酶（SDR）超家族的成员介导。尽管这些酶的生理作用并不总是很清楚，但它们在保护生物体免受有毒羰基化合物积累造成的损害方面的重要作用已得到普遍认可。最近，已确定SDR酶11β-羟基类固醇脱氢酶-1除了代谢其生理性糖皮质激素底物外，在非甾体羰基化合物的解毒中也发挥重要作用。本综述总结了目前关于1型11β-羟基类固醇脱氢酶的知识，并讨论了可能的底物/抑制剂相互作用。它们可能会损害糖皮质激素的生理功能或非甾体羰基化合物的解毒作用。
