Rowland P, Mirro J
Children's Hospital of Pittsburgh, Pennsylvania, USA.
Curr Opin Hematol. 1994 Jul;1(4):303-9.
Hematopoiesis occurs in a microenvironment containing a variety of growth factors. Normal hematopoietic cells require these growth factors for viability, proliferation, and differentiation. The purification and molecular cloning of human growth factors has permitted a detailed analysis of hematopoiesis. Furthermore, the commercial production of growth factors resulted in their widespread introduction into clinical practice to limit chemotherapy-induced neutropenia. Recently, clinical trials of growth factors have expanded to test their direct anticancer effects, to improve the efficacy of chemotherapy by stimulating cell division, and to use them as biological modulators to inhibit tumor growth. This review focuses on a few clinical uses of recombinant growth factors.
造血作用发生在含有多种生长因子的微环境中。正常造血细胞的存活、增殖和分化需要这些生长因子。人类生长因子的纯化和分子克隆使得对造血作用进行详细分析成为可能。此外，生长因子的商业生产导致其广泛应用于临床实践，以减轻化疗引起的中性粒细胞减少。最近，生长因子的临床试验已经扩展到测试其直接抗癌作用、通过刺激细胞分裂提高化疗疗效以及将它们用作抑制肿瘤生长的生物调节剂。这篇综述重点关注重组生长因子的一些临床应用。
