Veneselli E, Conte M, Biancheri R, Acquaviva A, De Bernardi B
Department of Pediatric Neuropsychiatry, University of Genoa, Italy.
Med Pediatr Oncol. 1998 Jan;30(1):15-7. doi: 10.1002/(sici)1096-911x(199801)30:1<15::aid-mpo6>3.0.co;2-3.
The authors describe a case of an 8-month-old boy with opsoclonus-myoclonus syndrome (OMS) and coincident unresectable neuroblastoma (NB). He achieved a complete remission for NB after 6 courses of standard-dose chemotherapy without significant neurological improvement despite the use of steroids and high-dose immunoglobulin (HIG), administered separately. Only the combined treatment withthese two drugs induced a complete disappearance of neurological symptoms. On the basis of this experience, the authors suggest the association of steroids plus HIG for the treatment of OMS in patients not responsive to conventional first line therapy with steroids.
