A-myb的过表达诱导鸡神经视网膜细胞依赖碱性成纤维细胞生长因子的增殖。
Overexpression of A-myb induces basic fibroblast growth factor-dependent proliferation of chicken neuroretina cells.
作者信息
Turque N, Plaza S, Klempnauer K H, Saule S
机构信息
CNRS EP560, Institut Pasteur de Lille, France.
出版信息
J Virol. 1997 Dec;71(12):9778-81. doi: 10.1128/JVI.71.12.9778-9781.1997.
Abstract
A-Myb behaves similarly to c-Myb in chicken neuroretina cells in its ability to induce fibroblast-like differentiation, to promote growth in the presence of basic fibroblast growth factor (bFGF), and to induce Pax-6 and mim-1 expression. The one difference between c-Myb and A-Myb in these cells is that the former but not the latter protein causes colony formation in soft agar in the presence of bFGF.
摘要
在鸡神经视网膜细胞中，A-Myb在诱导成纤维细胞样分化、在碱性成纤维细胞生长因子（bFGF）存在的情况下促进生长以及诱导Pax-6和mim-1表达的能力方面，表现得与c-Myb相似。在这些细胞中，c-Myb和A-Myb的一个区别在于，在bFGF存在的情况下，前者而非后者的蛋白质会导致在软琼脂中形成集落。
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