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A-myb的过表达诱导鸡神经视网膜细胞依赖碱性成纤维细胞生长因子的增殖。

Overexpression of A-myb induces basic fibroblast growth factor-dependent proliferation of chicken neuroretina cells.

作者信息

Turque N, Plaza S, Klempnauer K H, Saule S

机构信息

CNRS EP560, Institut Pasteur de Lille, France.

出版信息

J Virol. 1997 Dec;71(12):9778-81. doi: 10.1128/JVI.71.12.9778-9781.1997.

DOI:10.1128/JVI.71.12.9778-9781.1997
PMID:9371644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC230288/
Abstract

A-Myb behaves similarly to c-Myb in chicken neuroretina cells in its ability to induce fibroblast-like differentiation, to promote growth in the presence of basic fibroblast growth factor (bFGF), and to induce Pax-6 and mim-1 expression. The one difference between c-Myb and A-Myb in these cells is that the former but not the latter protein causes colony formation in soft agar in the presence of bFGF.

摘要

在鸡神经视网膜细胞中,A-Myb在诱导成纤维细胞样分化、在碱性成纤维细胞生长因子(bFGF)存在的情况下促进生长以及诱导Pax-6和mim-1表达的能力方面,表现得与c-Myb相似。在这些细胞中,c-Myb和A-Myb的一个区别在于,在bFGF存在的情况下,前者而非后者的蛋白质会导致在软琼脂中形成集落。

相似文献

1
Overexpression of A-myb induces basic fibroblast growth factor-dependent proliferation of chicken neuroretina cells.A-myb的过表达诱导鸡神经视网膜细胞依赖碱性成纤维细胞生长因子的增殖。
J Virol. 1997 Dec;71(12):9778-81. doi: 10.1128/JVI.71.12.9778-9781.1997.
2
Protein truncation is not required for c-myb proto-oncogene activity in neuroretina cells.在神经视网膜细胞中,c-myb原癌基因的活性并不需要蛋白质截短。
J Virol. 1992 Nov;66(11):6773-6. doi: 10.1128/JVI.66.11.6773-6776.1992.
3
Back-mutation of the V-Ets to the C-Ets carboxy-terminal amino acids in the P135gag-myb-ets results in chicken neuroretina cells transformation and loss of basic fibroblast growth factor responsiveness.在P135gag-myb-ets中,V-Ets向C-Ets羧基末端氨基酸的反向突变导致鸡神经视网膜细胞转化并丧失对碱性成纤维细胞生长因子的反应性。
Oncogene. 1996 Apr 4;12(7):1449-56.
4
C-Myb acts as transcriptional activator of the quail PAX6 (PAX-QNR) promoter through two different mechanisms.C-Myb 通过两种不同机制作为鹌鹑 PAX6(PAX-QNR)启动子的转录激活因子。
Oncogene. 1995 Jan 19;10(2):329-40.
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c-Myb is required for neural progenitor cell proliferation and maintenance of the neural stem cell niche in adult brain.c-Myb是成年大脑中神经祖细胞增殖和神经干细胞微环境维持所必需的。
Stem Cells. 2008 Jan;26(1):173-81. doi: 10.1634/stemcells.2007-0293. Epub 2007 Sep 27.
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Regulation of fibroblast growth factor 2 expression in melanoma cells by the c-MYB proto-oncoprotein.c-MYB原癌蛋白对黑色素瘤细胞中纤维母细胞生长因子2表达的调控
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The chicken A-myb protein is a transcriptional activator.鸡A-myb蛋白是一种转录激活因子。
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Definition of functional domains in P135gag-myb-ets and p48v-myb proteins required to maintain the response of neuroretina cells to basic fibroblast growth factor.维持神经视网膜细胞对碱性成纤维细胞生长因子反应所需的P135gag-myb-ets和p48v-myb蛋白中功能域的定义。
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本文引用的文献

1
Arrest of spermatogenesis and defective breast development in mice lacking A-myb.缺乏A-myb的小鼠精子发生停滞及乳腺发育缺陷
Nature. 1997 Apr 17;386(6626):713-7. doi: 10.1038/386713a0.
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Expression of mouse c-myb during embryonic development.小鼠c-myb在胚胎发育过程中的表达。
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Characterization of quail Pax-6 (Pax-QNR) proteins expressed in the neuroretina.在神经视网膜中表达的鹌鹑Pax-6(Pax-QNR)蛋白的特性分析。
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4
Quail Pax-6 (Pax-QNR) encodes a transcription factor able to bind and trans-activate its own promoter.鹌鹑Pax-6(Pax-QNR)编码一种能够结合并反式激活其自身启动子的转录因子。
Cell Growth Differ. 1993 Dec;4(12):1041-50.
5
The chicken A-myb protein is a transcriptional activator.鸡A-myb蛋白是一种转录激活因子。
Oncogene. 1994 Sep;9(9):2481-8.
6
The human A-myb protein is a strong activator of transcription.人类A-myb蛋白是一种强大的转录激活剂。
Oncogene. 1994 Sep;9(9):2469-79.
7
Pax-QNR/Pax-6, a paired box- and homeobox-containing gene expressed in neurons, is also expressed in pancreatic endocrine cells.Pax-QNR/Pax-6是一种在神经元中表达的含有配对盒和同源盒的基因,它也在胰腺内分泌细胞中表达。
Mol Endocrinol. 1994 Jul;8(7):929-38. doi: 10.1210/mend.8.7.7984154.
8
Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans.果蝇无眼基因与小鼠小眼基因及人类无虹膜基因的同源性。
Science. 1994 Aug 5;265(5173):785-9. doi: 10.1126/science.7914031.
9
C-Myb acts as transcriptional activator of the quail PAX6 (PAX-QNR) promoter through two different mechanisms.C-Myb 通过两种不同机制作为鹌鹑 PAX6(PAX-QNR)启动子的转录激活因子。
Oncogene. 1995 Jan 19;10(2):329-40.
10
Mouse A-myb encodes a trans-activator and is expressed in mitotically active cells of the developing central nervous system, adult testis and B lymphocytes.小鼠A-myb编码一种反式激活因子,在发育中的中枢神经系统、成年睾丸和B淋巴细胞的有丝分裂活跃细胞中表达。
EMBO J. 1994 Dec 15;13(24):5994-6005. doi: 10.1002/j.1460-2075.1994.tb06945.x.