多巴酚丁胺对冠心病患者和非冠心病患者血流动力学及冠状动脉血流的影响。
Influence of dobutamine on hemodynamics and coronary blood flow in patients with and without coronary artery disease.
作者信息
Meyer S L, Curry G C, Donsky M S, Twieg D B, Parkey R W, Willerson J T
出版信息
Am J Cardiol. 1976 Jul;38(1):103-8. doi: 10.1016/0002-9149(76)90070-9.
The influence of dobutamine on hemodynamics and coronary blood flow was studied in patients after routine cardiac catheterization. The data demonstrated that dobutamine is a powerful inotropic agent at a dose that has a relatively small influence on heart rate. In patients without coronary artery disease dobutamine greatly increased coronary arterial perfusion. In patients with severe coronary artery diseases dobutamine resulted in a much smaller increase in coronary perfusion, and the pattern of perfusion became more inhomogeneous. The results suggest that dobutamine has a potential inotropic value but raise concern about its influence on regional myocardial perfusion in patients with serious coronary artery disease.
在接受常规心导管检查的患者中研究了多巴酚丁胺对血流动力学和冠状动脉血流量的影响。数据表明，多巴酚丁胺在对心率影响相对较小的剂量下是一种强效的正性肌力药物。在无冠状动脉疾病的患者中，多巴酚丁胺可显著增加冠状动脉灌注。在患有严重冠状动脉疾病的患者中，多巴酚丁胺导致冠状动脉灌注的增加幅度小得多，且灌注模式变得更加不均匀。结果表明，多巴酚丁胺具有潜在的正性肌力价值，但对其在严重冠状动脉疾病患者中对局部心肌灌注的影响令人担忧。
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