多巴酚丁胺用于慢性缺血性心力衰竭：左心室功能及冠状动脉血流动力学的改变
Dobutamine in chronic ischemic heart failure: alterations in left ventricular function and coronary hemodynamics.
作者信息
Bendersky R, Chatterjee K, Parmley W W, Brundage B H, Ports T A
出版信息
Am J Cardiol. 1981 Sep;48(3):554-8. doi: 10.1016/0002-9149(81)90087-4.
Changes in cardiac performance and coronary hemodynamics were evaluated during dobutamine infusion in patients with chronic heart failure associated with ischemic heart disease. At the maximal administered dose (10 micrograms/kg per min) cardiac index increased by 54 percent and stroke work index by 65 percent, indicating improved left ventricular function. Coronary sinus flow and myocardial oxygen consumption increased concomitantly, but myocardial lactate production occurred in only one of eight patients. These findings suggest that improved left ventricular function with dobutamine is associated with increased myocardial oxygen consumption; however, overt myocardial ischemia occurs infrequently.
在患有与缺血性心脏病相关的慢性心力衰竭患者中，在多巴酚丁胺输注期间评估心脏功能和冠状动脉血流动力学的变化。在最大给药剂量（每分钟10微克/千克）时，心脏指数增加了54%，每搏功指数增加了65%，表明左心室功能得到改善。冠状窦血流量和心肌耗氧量同时增加，但仅8名患者中的1名出现心肌乳酸生成。这些发现表明，多巴酚丁胺改善左心室功能与心肌耗氧量增加有关；然而，明显的心肌缺血很少发生。
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