一个同源异型域基因Ptx3在中脑多巴胺能神经元中具有高度受限的脑表达。
A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons.
作者信息
Smidt M P, van Schaick H S, Lanctôt C, Tremblay J J, Cox J J, van der Kleij A A, Wolterink G, Drouin J, Burbach J P
机构信息
Rudolf Magnus Institute for Neurosciences, Department of Medical Pharmacology, Medical Faculty, Utrecht University, The Netherlands.
出版信息
Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13305-10. doi: 10.1073/pnas.94.24.13305.
Abstract
The mesencephalic dopaminergic (mesDA) system regulates behavior and movement control and has been implicated in psychiatric and affective disorders. We have identified a bicoid-related homeobox gene, Ptx3, a member of the Ptx-subfamily, that is uniquely expressed in these neurons. Its expression starting at E11.5 in the developing mouse midbrain correlates with the appearance of mesDA neurons. The number of Ptx3-expressing neurons is reduced in Parkinson patients, and these neurons are absent from 6-hydroxydopamine-lesioned rats, an animal model for this disease. Thus, Ptx3 is a unique transcription factor marking the mesDA neurons at the exclusion of other dopaminergic neurons, and it may be involved in developmental determination of this neuronal lineage.
摘要
中脑多巴胺能（mesDA）系统调节行为和运动控制，并与精神和情感障碍有关。我们已经鉴定出一个与双尾相关的同源框基因Ptx3，它是Ptx亚家族的成员，在这些神经元中特异性表达。它在发育中的小鼠中脑从胚胎第11.5天开始表达，与mesDA神经元的出现相关。帕金森病患者中表达Ptx3的神经元数量减少，在该疾病的动物模型6-羟基多巴胺损伤的大鼠中这些神经元缺失。因此，Ptx3是一种独特的转录因子，可标记mesDA神经元而排除其他多巴胺能神经元，并且它可能参与该神经元谱系的发育决定。
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