Miles S
University of California, Los Angeles, USA.
Curr Opin Hematol. 1995 May;2(3):227-33. doi: 10.1097/00062752-199502030-00012.
Human immunodeficiency virus infection causes multilineage hematopoietic defects. Defects in the production and function of CD4+ helper cells have been the focus of the majority of HIV research, but anemia, neutropenia, and thrombocytopenia are significant clinical problems as well. Bone marrow suppression is the dose-limiting toxicity for a number of antiviral and prophylactic medications. Hematopoietic growth factors such as granulocyte colony-stimulating factor or granulocyte-macrophage colony-stimulating factor are used to optimize the delivery of antiretroviral and prophylactic therapy. Because of the expense involved, the most appropriate use of these hematopoietic growth factors remains a subject of intense investigation. This review focuses on recent experimental results.
人类免疫缺陷病毒感染会导致多谱系造血缺陷。CD4+辅助性细胞生成及功能的缺陷一直是大多数HIV研究的重点，但贫血、中性粒细胞减少和血小板减少也是严重的临床问题。骨髓抑制是多种抗病毒和预防性药物的剂量限制性毒性。造血生长因子，如粒细胞集落刺激因子或粒细胞-巨噬细胞集落刺激因子，被用于优化抗逆转录病毒和预防性治疗的给药。由于涉及费用问题，这些造血生长因子的最恰当使用仍是深入研究的课题。本综述聚焦于近期的实验结果。
