癌性胸膜炎患者胸腔积液中唾液酸化路易斯X-i抗原水平升高。

Elevated sialyl Lewis X-i antigen levels in pleural effusions in patients with carcinomatous pleuritis.

作者信息

Ishikawa H, Satoh H, Kamma H, Naito T, Yamashita Y T, Ohtsuka M, Hasegawa S

机构信息

Department of Internal Medicine, Tsukuba Medical Center Hospital.

出版信息

Intern Med. 1997 Oct;36(10):685-9. doi: 10.2169/internalmedicine.36.685.

DOI:10.2169/internalmedicine.36.685

PMID:9372327

Abstract

The levels of sialyl Lewis X-i antigen (SLX), which is one of the cancer-associated carbohydrate antigens, were evaluated in 83 malignant and 46 benign pleural effusions. SLX levels in pleural effusion due to lung adenocarcinoma were significantly higher than those due to benign diseases (p < 0.0001), lung cancer other than adenocarcinoma (p = 0.0052), and adenocarcinoma originating from other organs (p = 0.0492). According to receiver operating characteristic (ROC) curve analysis, the optimal cut-off level in the discrimination between malignant and benign pleural effusions was 92 U/ml, which gave a sensitivity of 57.1% and a specificity of 77.8%. The cut-off level of pleural effusion in patients with carcinomatous pleuritis might be higher than that of serum (38 U/ml).

摘要

唾液酸化路易斯X-i抗原（SLX）是一种与癌症相关的碳水化合物抗原，对83例恶性胸腔积液和46例良性胸腔积液中的该抗原水平进行了评估。肺腺癌所致胸腔积液中的SLX水平显著高于良性疾病（p<0.0001）、非腺癌性肺癌（p=0.0052）以及源自其他器官的腺癌（p=0.0492）。根据受试者工作特征（ROC）曲线分析，鉴别恶性和良性胸腔积液的最佳临界值为92 U/ml，其灵敏度为57.1%，特异度为77.8%。癌性胸膜炎患者胸腔积液的临界值可能高于血清临界值（38 U/ml）。