Pleural Medicine Unit, Arnau de Vilanova University Hospital, Biomedical Research Institute of Lleida, Lleida, Spain.
Department of Laboratory Medicine, Arnau de Vilanova University Hospital, Biomedical Research Institute of Lleida, Lleida, Spain.
Respirology. 2015 Jul;20(5):831-3. doi: 10.1111/resp.12543. Epub 2015 Apr 14.
In this retrospective study of 80 pleural effusions, the combination of thyroid transcription factor 1 (TTF-1) and napsin A immunostaining on fluid cell blocks was positive in 80% of lung adenocarcinomas. Although measuring TTF-1 pleural fluid concentrations was of no value, quantification of napsin A levels allowed the identification of one third of the double-negative stained lung adenocarcinomas, with an overall accuracy similar to classical tumour markers for malignant-benign discrimination (sensitivity 40%, specificity 100%).
在这项 80 例胸腔积液的回顾性研究中，甲状腺转录因子 1（TTF-1）和液基细胞学块上 napsin A 免疫染色的联合应用在 80%的肺腺癌中呈阳性。尽管测量 TTF-1 胸腔积液浓度没有价值，但 napsin A 水平的定量可以识别三分之一的双阴性染色肺腺癌，其总体准确性与用于良恶性鉴别的经典肿瘤标志物相似（敏感性 40%，特异性 100%）。
