从红鳍东方鲀中鉴定出一种achaete-scute同源物Fash1。
Identification of an achaete-scute homolog, Fash1, from Fugu rubripes.
作者信息
Verma-Kurvari S, Johnson J E
机构信息
Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas 75235-9111, USA.
出版信息
Gene. 1997 Oct 24;200(1-2):145-8. doi: 10.1016/s0378-1119(97)00394-6.
Proteins of the achaete-scute family of transcription factors play important roles in neurogenesis in both invertebrates and vertebrates. Here, we report the cloning and characterization of a Japanese pufferfish, Fugu rubripes achaete-scute homolog 1, Fash1. Sequence alignment of the predicted amino acid sequence of Fash1 with other vertebrate homologs of the achaete scute homolog 1 subclass shows that the carboxyl 2/3 of the protein, including the basic helix-loop-helix, a putative nuclear localization signal and several consensus phosphorylation sites, is highly conserved. Strikingly, the similarity in this region between eight vertebrate species is close to 90%.
achaete - scute转录因子家族的蛋白质在无脊椎动物和脊椎动物的神经发生过程中都发挥着重要作用。在此，我们报告了日本河豚红鳍东方鲀achaete - scute同源物1（Fash1）的克隆与特性分析。Fash1预测氨基酸序列与achaete scute同源物1亚类的其他脊椎动物同源物的序列比对表明，该蛋白质的羧基端2/3，包括碱性螺旋 - 环 - 螺旋结构、一个假定的核定位信号以及几个共有磷酸化位点，具有高度保守性。令人惊讶的是，八个脊椎动物物种在该区域的相似性接近90%。
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