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Intracellular antibodies (intrabodies) as research reagents and therapeutic molecules for gene therapy.

作者信息

Marasco W A

机构信息

Division of Human Retrovirology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Immunotechnology. 1995 May;1(1):1-19. doi: 10.1016/1380-2933(95)00001-1.

DOI:10.1016/1380-2933(95)00001-1

PMID:9373329

Abstract

摘要

相似文献

Intracellular antibodies (intrabodies) as research reagents and therapeutic molecules for gene therapy.

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Intracellular antibodies (intrabodies) for gene therapy of infectious diseases.

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Intrabodies as drug discovery tools and therapeutics.

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Intracellular antibodies against HIV-1 envelope protein for AIDS gene therapy.

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Intracellular antibodies (intrabodies) and their therapeutic potential.

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Generation of antibody molecules through antibody engineering.

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引用本文的文献

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Expression of recombinant antibody (single chain antibody fragment) in transgenic plant Nicotiana tabacum cv. Xanthi.

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Recombinant rabbit single-chain antibodies bind to the catalytic and C-terminal domains of HIV-1 integrase protein and strongly inhibit HIV-1 replication.

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Potential applications of intracellular antibodies (intrabodies) in stem cell therapeutics.

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Role of native-state topology in the stabilization of intracellular antibodies.

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Antibody-based resistance to plant pathogens.

Transgenic Res. 2001;10(1):1-12. doi: 10.1023/a:1008945126359.

Apoplastic and cytosolic expression of full-size antibodies and antibody fragments in Nicotiana tabacum.

Transgenic Res. 1999 Aug;8(4):255-63. doi: 10.1023/a:1008937011213.

Inhibition of human immunodeficiency virus type 1 replication in vitro by a novel combination of anti-Tat single-chain intrabodies and NF-kappa B antagonists.

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Intracellular antibodies (intrabodies) as research reagents and therapeutic molecules for gene therapy.

作者信息

Marasco W A

机构信息

Division of Human Retrovirology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Immunotechnology. 1995 May;1(1):1-19. doi: 10.1016/1380-2933(95)00001-1.

DOI:10.1016/1380-2933(95)00001-1

PMID:9373329

Abstract

摘要

相似文献

Intracellular antibodies (intrabodies) as research reagents and therapeutic molecules for gene therapy.

Immunotechnology. 1995 May;1(1):1-19. doi: 10.1016/1380-2933(95)00001-1.

Engineering a growth sensor to select intracellular antibodies in the cytosol of mammalian cells.

J Biosci Bioeng. 2017 Jul;124(1):125-132. doi: 10.1016/j.jbiosc.2017.02.017. Epub 2017 Mar 17.

Intracellular antibodies (intrabodies) for gene therapy of infectious diseases.

Annu Rev Microbiol. 1997;51:257-83. doi: 10.1146/annurev.micro.51.1.257.

Intrabody and Parkinson's disease.

Biochim Biophys Acta. 2009 Jul;1792(7):634-42. doi: 10.1016/j.bbadis.2008.09.001. Epub 2008 Sep 12.

Intracellular antibodies as specific reagents for functional ablation: future therapeutic molecules.

Curr Mol Med. 2004 Aug;4(5):519-28. doi: 10.2174/1566524043360384.

Intrabodies as drug discovery tools and therapeutics.

Curr Opin Chem Biol. 2005 Aug;9(4):359-65. doi: 10.1016/j.cbpa.2005.06.003.

Intracellular antibodies against HIV-1 envelope protein for AIDS gene therapy.

Hum Gene Ther. 1998 Jul 20;9(11):1627-42. doi: 10.1089/hum.1998.9.11-1627.

Blocking translocation of cell surface molecules from the ER to the cell surface by intracellular antibodies targeted to the ER.

J Cell Mol Med. 2007 Jan-Feb;11(1):54-70. doi: 10.1111/j.1582-4934.2007.00002.x.

Intracellular antibodies (intrabodies) and their therapeutic potential.

Handb Exp Pharmacol. 2008(181):343-73. doi: 10.1007/978-3-540-73259-4_15.

Generation of antibody molecules through antibody engineering.

Methods Mol Biol. 2003;207:3-25. doi: 10.1385/1-59259-334-8:03.

引用本文的文献

Transbody against virus core protein potently inhibits hepadnavirus replication in vivo: evidence from a duck model of hepatitis B virus.

Br J Pharmacol. 2017 Jul;174(14):2261-2272. doi: 10.1111/bph.13811. Epub 2017 Jun 7.

Camelid nanobodies with high affinity for broad bean mottle virus: a possible promising tool to immunomodulate plant resistance against viruses.

Plant Mol Biol. 2015 Mar;87(4-5):355-69. doi: 10.1007/s11103-015-0282-5. Epub 2015 Feb 4.

Expression of recombinant antibody (single chain antibody fragment) in transgenic plant Nicotiana tabacum cv. Xanthi.

Mol Biol Rep. 2013 Dec;40(12):7027-37. doi: 10.1007/s11033-013-2822-x. Epub 2013 Nov 12.

Recombinant rabbit single-chain antibodies bind to the catalytic and C-terminal domains of HIV-1 integrase protein and strongly inhibit HIV-1 replication.

Biotechnol Appl Biochem. 2012 Sep-Oct;59(5):353-66. doi: 10.1002/bab.1034. Epub 2012 Oct 10.

Potential applications of intracellular antibodies (intrabodies) in stem cell therapeutics.

J Cell Mol Med. 2005 Jan-Mar;9(1):191-5. doi: 10.1111/j.1582-4934.2005.tb00348.x.

The production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi.

Microb Cell Fact. 2003 Jan 30;2(1):1. doi: 10.1186/1475-2859-2-1.

Role of native-state topology in the stabilization of intracellular antibodies.

Biophys J. 2001 Nov;81(5):2935-45. doi: 10.1016/S0006-3495(01)75933-4.

Antibody-based resistance to plant pathogens.

Transgenic Res. 2001;10(1):1-12. doi: 10.1023/a:1008945126359.

Apoplastic and cytosolic expression of full-size antibodies and antibody fragments in Nicotiana tabacum.

Transgenic Res. 1999 Aug;8(4):255-63. doi: 10.1023/a:1008937011213.

Inhibition of human immunodeficiency virus type 1 replication in vitro by a novel combination of anti-Tat single-chain intrabodies and NF-kappa B antagonists.

J Virol. 1997 Sep;71(9):6486-94. doi: 10.1128/JVI.71.9.6486-6494.1997.