• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Intracellular antibodies (intrabodies) as research reagents and therapeutic molecules for gene therapy.

作者信息

Marasco W A

机构信息

Division of Human Retrovirology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Immunotechnology. 1995 May;1(1):1-19. doi: 10.1016/1380-2933(95)00001-1.

DOI:10.1016/1380-2933(95)00001-1
PMID:9373329
Abstract
摘要

相似文献

1
Intracellular antibodies (intrabodies) as research reagents and therapeutic molecules for gene therapy.细胞内抗体(胞内抗体)作为基因治疗的研究试剂和治疗分子。
Immunotechnology. 1995 May;1(1):1-19. doi: 10.1016/1380-2933(95)00001-1.
2
Engineering a growth sensor to select intracellular antibodies in the cytosol of mammalian cells.
J Biosci Bioeng. 2017 Jul;124(1):125-132. doi: 10.1016/j.jbiosc.2017.02.017. Epub 2017 Mar 17.
3
Intracellular antibodies (intrabodies) for gene therapy of infectious diseases.用于传染病基因治疗的细胞内抗体
Annu Rev Microbiol. 1997;51:257-83. doi: 10.1146/annurev.micro.51.1.257.
4
Intrabody and Parkinson's disease.体内抗体与帕金森病。
Biochim Biophys Acta. 2009 Jul;1792(7):634-42. doi: 10.1016/j.bbadis.2008.09.001. Epub 2008 Sep 12.
5
Intracellular antibodies as specific reagents for functional ablation: future therapeutic molecules.作为功能消融特异性试剂的细胞内抗体:未来的治疗分子。
Curr Mol Med. 2004 Aug;4(5):519-28. doi: 10.2174/1566524043360384.
6
Intrabodies as drug discovery tools and therapeutics.作为药物发现工具和治疗手段的胞内抗体。
Curr Opin Chem Biol. 2005 Aug;9(4):359-65. doi: 10.1016/j.cbpa.2005.06.003.
7
Intracellular antibodies against HIV-1 envelope protein for AIDS gene therapy.用于艾滋病基因治疗的抗HIV-1包膜蛋白细胞内抗体。
Hum Gene Ther. 1998 Jul 20;9(11):1627-42. doi: 10.1089/hum.1998.9.11-1627.
8
Blocking translocation of cell surface molecules from the ER to the cell surface by intracellular antibodies targeted to the ER.通过靶向内质网的细胞内抗体阻断细胞表面分子从内质网到细胞表面的转运。
J Cell Mol Med. 2007 Jan-Feb;11(1):54-70. doi: 10.1111/j.1582-4934.2007.00002.x.
9
Intracellular antibodies (intrabodies) and their therapeutic potential.细胞内抗体及其治疗潜力。
Handb Exp Pharmacol. 2008(181):343-73. doi: 10.1007/978-3-540-73259-4_15.
10
Generation of antibody molecules through antibody engineering.通过抗体工程产生抗体分子。
Methods Mol Biol. 2003;207:3-25. doi: 10.1385/1-59259-334-8:03.

引用本文的文献

1
Transbody against virus core protein potently inhibits hepadnavirus replication in vivo: evidence from a duck model of hepatitis B virus.抗病毒核心蛋白的反式载体在体内有效抑制嗜肝DNA病毒复制:来自乙型肝炎病毒鸭模型的证据
Br J Pharmacol. 2017 Jul;174(14):2261-2272. doi: 10.1111/bph.13811. Epub 2017 Jun 7.
2
Camelid nanobodies with high affinity for broad bean mottle virus: a possible promising tool to immunomodulate plant resistance against viruses.高亲合力针对菜豆黄花叶病毒的骆驼纳米抗体:一种可能有前途的免疫调节植物抗病毒抗性的工具。
Plant Mol Biol. 2015 Mar;87(4-5):355-69. doi: 10.1007/s11103-015-0282-5. Epub 2015 Feb 4.
3
Expression of recombinant antibody (single chain antibody fragment) in transgenic plant Nicotiana tabacum cv. Xanthi.
在转基因烟草(黄花烟草)中表达重组抗体(单链抗体片段)。
Mol Biol Rep. 2013 Dec;40(12):7027-37. doi: 10.1007/s11033-013-2822-x. Epub 2013 Nov 12.
4
Recombinant rabbit single-chain antibodies bind to the catalytic and C-terminal domains of HIV-1 integrase protein and strongly inhibit HIV-1 replication.重组兔单链抗体与 HIV-1 整合酶蛋白的催化和 C 末端结构域结合,并强烈抑制 HIV-1 的复制。
Biotechnol Appl Biochem. 2012 Sep-Oct;59(5):353-66. doi: 10.1002/bab.1034. Epub 2012 Oct 10.
5
Potential applications of intracellular antibodies (intrabodies) in stem cell therapeutics.细胞内抗体在干细胞治疗中的潜在应用。
J Cell Mol Med. 2005 Jan-Mar;9(1):191-5. doi: 10.1111/j.1582-4934.2005.tb00348.x.
6
The production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi.酵母和丝状真菌产生抗体片段及抗体融合蛋白。
Microb Cell Fact. 2003 Jan 30;2(1):1. doi: 10.1186/1475-2859-2-1.
7
Role of native-state topology in the stabilization of intracellular antibodies.天然态拓扑结构在细胞内抗体稳定中的作用。
Biophys J. 2001 Nov;81(5):2935-45. doi: 10.1016/S0006-3495(01)75933-4.
8
Antibody-based resistance to plant pathogens.基于抗体的植物病原体抗性。
Transgenic Res. 2001;10(1):1-12. doi: 10.1023/a:1008945126359.
9
Apoplastic and cytosolic expression of full-size antibodies and antibody fragments in Nicotiana tabacum.全尺寸抗体和抗体片段在烟草中的质外体和胞质表达。
Transgenic Res. 1999 Aug;8(4):255-63. doi: 10.1023/a:1008937011213.
10
Inhibition of human immunodeficiency virus type 1 replication in vitro by a novel combination of anti-Tat single-chain intrabodies and NF-kappa B antagonists.抗Tat单链抗体与NF-κB拮抗剂的新型组合在体外对1型人类免疫缺陷病毒复制的抑制作用
J Virol. 1997 Sep;71(9):6486-94. doi: 10.1128/JVI.71.9.6486-6494.1997.