Schoenbaum S C, Baker O, Jezek Z
Am J Epidemiol. 1976 Jul;104(1):74-80. doi: 10.1093/oxfordjournals.aje.a112275.
Sixty-one clinical cases of hepatitis occurred in Ogemaw County, Michigan, in late April and May 1968. The clustering of cases in time and the high attack rate for persons 10-19 years of age suggested a common source of exposure. Investigation implicated a local bakery, where one of the employees directly involved in the baking had had an icteric illness one month before the outbreak. Comparison of exposure histories of patients versus healthy family members established pastries covered with glaze or icing as the vehicle of infection. The glaze and icing were applied to the pastries after all baking had been completed. During the epidemic, immune serum globulin was given on a community-wide basis. No secondary cases of hepatitis were identified.
1968年4月下旬至5月期间，密歇根州奥杰马县出现了61例肝炎临床病例。病例在时间上的聚集以及10至19岁人群的高发病率表明存在共同的暴露源。调查发现一家当地面包店有问题，在疫情爆发前一个月，一名直接参与烘焙的员工患了黄疸病。通过比较患者与健康家庭成员的暴露史，确定覆盖有糖霜或糖衣的糕点为感染载体。所有烘焙完成后，才给糕点涂抹糖霜和糖衣。疫情期间，在社区范围内注射了免疫血清球蛋白。未发现肝炎二代病例。
