Müller R A, Chugani H T, Muzik O, Rothermel R D, Chakraborty P K
Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, USA.
J Child Neurol. 1997 Oct;12(7):431-7. doi: 10.1177/088307389701200704.
This study examines whether or not in Sturge-Weber syndrome hypoperfused brain areas that are affected by calcification continue to retain some function and participate in language and motor activations. [15O]-Water positron emission tomography (PET) was used for brain mapping of these functions in two patients with extensive unilateral calcification and hypoperfusion and in one patient with calcification and hypoperfusion restricted to the left posterior region. Task-related regional cerebral blood flow changes suggest that (1) hypoperfused areas may become activated during language and motor performance, and (2) progressive calcification in Sturge-Weber syndrome is associated with functional reorganization in the language and motor domains. Interhemispheric reorganization appears to be more pronounced for language than for motor functions.
本研究探讨在斯特奇-韦伯综合征中，受钙化影响的灌注不足脑区是否仍保留某些功能，并参与语言和运动激活。使用[15O]-水正电子发射断层扫描（PET）对两名广泛单侧钙化和灌注不足的患者以及一名钙化和灌注不足局限于左后区域的患者进行这些功能的脑图谱绘制。与任务相关的局部脑血流变化表明：（1）灌注不足区域在语言和运动表现期间可能被激活；（2）斯特奇-韦伯综合征中的进行性钙化与语言和运动领域的功能重组有关。半球间重组在语言方面似乎比运动功能更为明显。
