Young L S, Dawson C W, Eliopoulos A G
CRC Institute for Cancer Studies, University of Birmingham Medical School, UK.
Br Med Bull. 1997;53(3):509-21. doi: 10.1093/oxfordjournals.bmb.a011627.
Virus infection and replication are often associated with apoptosis and this effect is likely to be responsible for much of the pathology associated with infectious disease. Many viruses encode proteins which can inhibit apoptosis thereby either prolonging the survival of infected cells such that the production of progeny virus is maximised or facilitating the establishment of virus persistence. These viral proteins target the cellular pathways responsible for regulating apoptosis and have been instrumental in furthering our understanding of the apoptotic process. Many of the viruses associated with oncogenic transformation have adopted strategies for blocking apoptosis highlighting the centrality of this effect in carcinogenesis. Understanding the mechanisms by which viruses regulate apoptosis may lead to the development of novel therapies for both infectious disease and cancer.
病毒感染和复制通常与细胞凋亡相关，这种效应可能是许多传染病相关病理的原因。许多病毒编码能够抑制细胞凋亡的蛋白质，从而延长受感染细胞的存活时间，使子代病毒的产生最大化，或者促进病毒持续性感染的建立。这些病毒蛋白靶向负责调节细胞凋亡的细胞途径，并有助于我们进一步了解细胞凋亡过程。许多与致癌转化相关的病毒都采取了阻断细胞凋亡的策略，突出了这种效应在致癌过程中的核心地位。了解病毒调节细胞凋亡的机制可能会为传染病和癌症开发新的治疗方法。
