Umezaki T, Zheng Y, Shiba K, Miller A D
The Rockefeller University, New York, NY 10021-6399, USA.
Brain Res. 1997 Sep 26;769(2):347-56. doi: 10.1016/s0006-8993(97)00756-7.
An ascending projection from the medullary nucleus retroambigualis (NRA) has recently been described as important for the control of the upper airway during vocalization. We evaluated the importance of this projection in other behaviors by making localized injections of the neurotoxin kainic acid in the NRA in decerebrate cats, most of which were paralyzed and artificially ventilated. In contrast to its importance for vocalization, the NRA is not essential for activation of upper airway musculature during respiration, swallowing, vomiting, or reflexes elicited by superior laryngeal or vestibular nerve afferents. However, kainic acid injections in the NRA and adjacent reticular formation prolonged the inhibitory phrenic motoneuronal response to superior laryngeal nerve stimulation and abolished or reduced abdominal motoneuronal responses during respiration, vomiting, and superior laryngeal nerve stimulation. Thus, of the behaviors we investigated, the importance of the ascending projection from the NRA appears to be limited to vocalization, while descending projections from the NRA region are important in a number of behaviors.
最近有研究表明，延髓后疑核（NRA）的上行投射对于发声过程中上呼吸道的控制至关重要。我们通过向去大脑猫的NRA局部注射神经毒素 kainic 酸，评估了该投射在其他行为中的重要性，其中大多数猫已瘫痪并进行人工通气。与它对发声的重要性相反，NRA对于呼吸、吞咽、呕吐或喉上神经或前庭神经传入引起的反射过程中上呼吸道肌肉组织的激活并非必不可少。然而，向NRA和相邻网状结构注射kainic酸会延长膈运动神经元对喉上神经刺激的抑制反应，并消除或减少呼吸、呕吐和喉上神经刺激期间腹部运动神经元的反应。因此，在我们研究的行为中，NRA的上行投射的重要性似乎仅限于发声，而NRA区域的下行投射在许多行为中都很重要。
