氯唑西林的穿透性

Cloxacillin penetration.

作者信息

Uwaydah M M, Faris B M, Samara I N, Shammas H F, To'Mey K F

出版信息

Am J Ophthalmol. 1976 Jul;82(1):114-6. doi: 10.1016/0002-9394(76)90675-9.

Abstract

We investigated the intraocular penetration of cloxacillin in 14 patients undergoing surgery for senile cataract after intramuscular and subconjunctival injections of the drug. No antibiotic level was detected in the aqueous humor when cloxacillin was administered intramuscularly in a dose that ranged between 1 and 4 g. With subconjunctival injection, therapeutically effective cloxacillin activity was detected in the aqueous humor only after a dose of 250 mg.

摘要

我们研究了14例接受老年性白内障手术的患者在肌内注射和结膜下注射氯唑西林后药物的眼内渗透性。当肌内注射剂量在1至4克之间的氯唑西林时，房水中未检测到抗生素水平。结膜下注射时，仅在剂量为250毫克后，房水中才检测到具有治疗效果的氯唑西林活性。