硫酸妥布霉素在人眼中的渗透情况。
Penetration of tobramycin sulphate into the human eye.
作者信息
Petounis A, Papapanos G, Karageorgiou-Makromihelaki C
出版信息
Br J Ophthalmol. 1978 Sep;62(9):660-2. doi: 10.1136/bjo.62.9.660.
Abstract
Tobramycin sulphate, a new aminoglycoside antibiotic, was injected intramuscularly (80 and 100 mg) and subconjunctivally (10 mg) into patients, and the concentrations of the drug in serum and aqueous humour were determined 1 hour after the injection by an agar wall diffusion plate method. The intramuscular administration of tobramycin produced insignificant and non-inhibitory concentrations in the aqueous humour, while therapeutically effective levels of the antibiotic appeared in the aqueous after subconjunctival administrationof tobramycin (mean: 18.9 microgram/ml). These data suggest that tobramycin sulphate may be of value in the treatment of ocular infections.
摘要
硫酸妥布霉素是一种新型氨基糖苷类抗生素，分别以80毫克和100毫克的剂量给患者肌内注射，以10毫克的剂量给患者结膜下注射，注射1小时后，采用琼脂壁扩散平板法测定血清和房水中该药物的浓度。肌内注射妥布霉素后，房水中的药物浓度无显著变化且无抑菌作用，而结膜下注射妥布霉素后，房水中出现了治疗有效的抗生素水平（平均：18.9微克/毫升）。这些数据表明硫酸妥布霉素可能对眼部感染的治疗有价值。
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