Johnson B L, Brown S I
Am J Ophthalmol. 1976 Jul;82(1):83-9. doi: 10.1016/0002-9394(76)90668-1.
A 6-month-old infant boy who had a unilateral congenital corneal opacification with adhesions of abnormal iris to the posterior cornea underwent corneal transplantation. Pathologic examination of the excised cornea showed a central defect in Bowman's layer, an absent Descemet's membrane, and multilayered squamous epithelium replaced the endothelial layer. Electron microscopy confirmed that these cells had epithelial characteristics with numerous desmosomes, microvilli, and abundant cytoplasmic tonofibrils. While the pathogenesis remains obscure, a metaplastic process early in gestation probably resulted in the presence of epithelial cells in the endothelial layer.
一名6个月大的男婴因单侧先天性角膜混浊且异常虹膜与角膜后表面粘连而接受了角膜移植手术。切除角膜的病理检查显示，Bowman层有中央缺损，Descemet膜缺失，多层鳞状上皮取代了内皮层。电子显微镜检查证实这些细胞具有上皮细胞特征，有大量桥粒、微绒毛和丰富的细胞质张力原纤维。虽然发病机制尚不清楚，但妊娠早期的化生过程可能导致内皮层出现上皮细胞。
