Vicini P, Caumo A, Cobelli C
Department of Electronics and Informatics, University of Padova, Italy.
Am J Physiol. 1997 Nov;273(5):E1024-32. doi: 10.1152/ajpendo.1997.273.5.E1024.
A two-compartment minimal model (2CMM) has been proposed [A. Caumo and C. Cobelli. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E829-E841, 1993] to describe intravenous glucose tolerance test (IVGTT) labeled (hereafter hot) glucose kinetics. This model, at variance with the one-compartment minimal model (1CMM), allows the estimation of a plausible profile of glucose production. The aim of this study is to show that the 2CMM also allows the assessment of insulin sensitivity (SI2*), glucose effectiveness (SG2*), and plasma clearance rate (PCR). The 2CMM was identified on stable-isotope IVGTTs performed in normal subjects (n = 14). Results were (means +/- SE) SG2* = 0.85 +/- 0.14 ml.kg-1.min-1, PCR = 2.02 +/- 0.14 ml.kg-1.min-1, and SI2* = 13.83 +/- 2.54 x 10(-2) ml.kg-1.min-1.microU-1.ml. The 1CMM was also identified; glucose effectiveness and insulin sensitivity indexes were SGV = 1.36 +/- 0.08 ml.kg-1.min-1 and SIV = 12.98 +/- 2.21 x 10(-2) ml.kg-1.min-1.microU-1.ml, respectively, where V is the 1CMM glucose distribution volume. SGV was lower than PCR and higher than SG2 and did not correlate with either [r = 0.45 (NS) and r = 0.50 (NS), respectively], whereas SIV was not different from and was correlated with SI2 (r = 0.95; P < 0.001). SG* compares well (r = 0.78; P < 0.001) with PCR normalized by the 2CMM total glucose distribution volume. In conclusion, the 2CMM is a powerful tool to assess glucose metabolism in vivo.
为描述静脉葡萄糖耐量试验（IVGTT）中标记（以下简称“热”）葡萄糖动力学，已提出一种两室最小模型（2CMM）[A. 考莫和C. 科贝利。《美国生理学杂志》264卷（内分泌与代谢27）：E829 - E841，1993年]。该模型与一室最小模型（1CMM）不同，能够估算出合理的葡萄糖生成曲线。本研究的目的是表明2CMM还可用于评估胰岛素敏感性（SI2*）、葡萄糖效能（SG2*）和血浆清除率（PCR）。在正常受试者（n = 14）中进行的稳定同位素IVGTT上确定了2CMM。结果为（均值±标准误）：SG2* = 0.85 ± 0.14 ml·kg⁻¹·min⁻¹，PCR = 2.02 ± 0.14 ml·kg⁻¹·min⁻¹，SI2* = 13.83 ± 2.54 × 10⁻² ml·kg⁻¹·min⁻¹·μU⁻¹·ml。还确定了1CMM；葡萄糖效能和胰岛素敏感性指数分别为SGV =1.36 ± 0.08 ml·kg⁻¹·min⁻¹和SIV = 12.98 ± 2.21 × 10⁻² ml·kg⁻¹·min⁻¹·μU⁻¹·ml，其中V为1CMM葡萄糖分布容积。SGV低于PCR且高于SG2，且与二者均无相关性[r分别为0.45（无显著性差异）和0.50（无显著性差异）]，而SIV与SI2无差异且具有相关性（r = 0.95；P < 0.001）。SG*与经2CMM总葡萄糖分布容积标准化后的PCR具有良好的相关性（r = 0.78；P < 0.001）。总之，2CMM是评估体内葡萄糖代谢的有力工具。
