Cymborowski B, King V
Department of Invertebrate Physiology, Warsaw University, Poland.
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1996 Nov;115(3):239-46. doi: 10.1016/s0742-8413(96)00103-x.
Expression of Fos-like immunoreactivity (FOS-lir) was examined in the brains of the blow fly Calliphora vicina for evidence of circadian regulation by photic stimuli. Fos-lir in various parts of the brain was investigated as a function of light and time of day. Immunohistochemistry demonstrated that photic stimuli have an inductive effect on c-fos expression in the various parts of the brain, but only in the neurons of the pars intercerebralis did the clear photic induction of c-fos expression occur at times when light was capable of phase-shifting circadian locomotor activity rhythms. This suggests that the c-fos gene may play a role in the photic pathway for circadian entrainment and that these neurons may be involved in the transduction of photic signals. Whether changes in c-fos expression are essential components of this pathway remains to be determined.
研究了红头丽蝇（Calliphora vicina）大脑中类Fos免疫反应性（FOS-lir）的表达情况，以寻找光刺激对昼夜节律调节的证据。研究了大脑不同部位的FOS-lir与光照和一天中时间的关系。免疫组织化学表明，光刺激对大脑各部位的c-fos表达有诱导作用，但只有在间脑中部的神经元中，c-fos表达的明显光诱导才会在光照能够使昼夜节律性运动活动节律发生相移的时候出现。这表明c-fos基因可能在昼夜节律光诱导途径中发挥作用，并且这些神经元可能参与光信号的转导。c-fos表达的变化是否是该途径的重要组成部分还有待确定。
