Pilo A, Navalesi R, Ferrannini E
Am J Physiol. 1976 Jun;230(6):1626-9. doi: 10.1152/ajplegacy.1976.230.6.1626.
The kinetics of insulin are commonly investigated by intravenous administration of labeled hormone, whereas native insulin is removed by the liver to some extent before mixing in the systemic circulation. A mathematical model has been developed which makes it possible to interpret the experimental data obtained by peripheral plasma sampling after portal and peripheral injection of the tracer. Equations are given that allow for the computation of metabolic clearance rate, initial distribution volume, production rate, and body mass of insulin. It is demonstrated that hepatic extraction can be calculated from the difference between the clearance rate values obtained after portal and peripheral injection of the tracer; an estimate of total hepatic catabolism is also derived. The assumptions and limitations underlying this mathematical analysis are discussed.
胰岛素的动力学通常通过静脉注射标记激素来研究，而天然胰岛素在进入体循环混合之前会在一定程度上被肝脏清除。现已开发出一种数学模型，该模型能够解释在门静脉和外周注射示踪剂后通过外周血浆采样获得的实验数据。给出了用于计算胰岛素的代谢清除率、初始分布容积、产生率和体重的方程。结果表明，肝脏提取率可根据门静脉和外周注射示踪剂后获得的清除率值之差来计算；还得出了肝脏总分解代谢的估计值。讨论了这种数学分析所依据的假设和局限性。
