Bloch M, Stager S, Braun A, Calis K A, Turcasso N M, Grothe D R, Rubinow D R
Department of Health and Human Services, National Institute of Mental Health, Bethesda, Md. 20892-1276, USA.
J Clin Psychiatry. 1997 Oct;58(10):433-6. doi: 10.4088/jcp.v58n1004.
Neuroleptic-related dysphoric reactions are well recognized in the context of psychiatric disorders, especially in association with extrapyramidal side effects. Very few controlled data exist regarding the effects of neuroleptics on the mood of psychiatrically "normal" subjects. In this study, the depressogenic effect of the neuroleptic drug pimozide was assessed in men without psychiatric disorders.
Eight men with developmental stuttering but no past or present psychiatric illness participated in a double-blind, placebo-controlled study assessing the effect of 6 weeks of pimozide treatment on speech fluency and mood.
Four of the seven subjects who were compliant with the treatment developed marked depressive symptoms. No clear association was found between these reactions and pimozide dose, blood level, or degree of neurologic side effects. Symptoms abated soon after drug discontinuation.
Pimozide induced significant depressive symptoms in this group of psychiatrically normal men who stutter. Neuroleptic drugs may have a causal effect in the induction of depression in psychiatrically normal subjects, ostensibly independent of dose or severity of neurologic side effects.
在精神疾病的背景下，抗精神病药物相关的烦躁反应已得到充分认识，尤其是与锥体外系副作用相关时。关于抗精神病药物对精神“正常”受试者情绪的影响，现有极少的对照数据。在本研究中，评估了抗精神病药物匹莫齐特对无精神疾病男性的致抑郁作用。
八名患有发育性口吃但既往及目前均无精神疾病的男性参与了一项双盲、安慰剂对照研究，该研究评估了为期6周的匹莫齐特治疗对言语流畅性和情绪的影响。
七名依从治疗的受试者中有四名出现了明显的抑郁症状。未发现这些反应与匹莫齐特剂量、血药浓度或神经副作用程度之间存在明确关联。停药后症状很快减轻。
匹莫齐特在这组患有口吃的精神正常男性中诱发了显著的抑郁症状。抗精神病药物可能在精神正常受试者中导致抑郁，表面上与剂量或神经副作用的严重程度无关。
