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[一种布地奈德粉剂治疗变应性鼻炎的新给药方法]

[A new method of administration of budesonide powder for the treatment of allergic rhinitis].

作者信息

Soler R, Mas S, Pineda J, Ruiz-Bravo C, Palacios R, Bernal M

机构信息

Servicio de ORL, Hospital Son Dureta, Palma de Mallorca.

出版信息

Acta Otorrinolaringol Esp. 1997 Jun-Jul;48(5):353-7.

PMID:9376155
Abstract

The efficacy and safety of a new device for administering powdered budesonide in allergic rhinitis was evaluated. This method eliminates the disadvantages of traditional preparations and improves dosing and administration, even at low nasal flow rates. A randomized, controlled, single-blind study was made in 66 patients with allergic rhinitis, half of whom were assigned to the experimental treatment (powdered budesonide) and half to a standard aerosol. Results showed that both preparations were very effective (p < 0.01) in controlling rhinitis symptoms and not significantly different. However, the overall patient evaluation was significantly better (p < 0.01) in the group treated with powdered budesonide. Both treatments elicited a similar tolerance, although tolerance of powdered budesonide was slightly better. To conclude, treatment with the new powdered budesonide dispenser was as effective and well-tolerated as standard treatment, and better accepted by patients.

摘要

对一种用于治疗变应性鼻炎的新型布地奈德粉剂给药装置的疗效和安全性进行了评估。这种方法消除了传统制剂的缺点,即使在低鼻流速情况下也能改善给药剂量和方式。对66例变应性鼻炎患者进行了一项随机、对照、单盲研究,其中一半患者被分配接受实验性治疗(布地奈德粉剂),另一半接受标准气雾剂治疗。结果显示,两种制剂在控制鼻炎症状方面都非常有效(p < 0.01),且无显著差异。然而,接受布地奈德粉剂治疗组的总体患者评价显著更好(p < 0.01)。两种治疗的耐受性相似,尽管布地奈德粉剂的耐受性略好。总之,新型布地奈德粉剂给药装置的治疗效果和耐受性与标准治疗相当,且更易被患者接受。

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