Bonneton F, Shaw P J, Fazakerley C, Shi M, Dover G A
Department of Genetics, University of Leicester, UK.
Mech Dev. 1997 Aug;66(1-2):143-56. doi: 10.1016/s0925-4773(97)00100-7.
Co-evolution between developmental regulatory elements is an important mechanism of evolution. This work compares the hunchback-bicoid interaction in the housefly Musca domestica with Drosophila melanogaster. The Musca HUNCHBACK protein is 66% conserved and partially rescues a hunchback mutant, yet the BICOID-dependent promoter (P2) of Musca hunchback is unexpectedly diverged from D. melanogaster. Introduced into D. melanogaster, this promoter drives a normal P2 pattern during the syncytial blastoderm stage but is expressed ectopically at the anterior pole of the embryo at later stages. We also report differences in the early expression of hunchback in Musca. We suggest that conservation of the morphogenetic function of bicoid in different sized embryos of higher diptera requires co-evolution of bicoid and its target binding sites.
发育调控元件之间的共同进化是一种重要的进化机制。这项工作比较了家蝇（Musca domestica）和黑腹果蝇（Drosophila melanogaster）中驼背蛋白（hunchback）与双胸蛋白（bicoid）的相互作用。家蝇的驼背蛋白（HUNCHBACK）有66%的保守性，并且能部分挽救驼背突变体，然而家蝇驼背蛋白依赖双胸蛋白的启动子（P2）却意外地与黑腹果蝇的不同。将这个启动子导入黑腹果蝇后，它在合胞体胚盘阶段驱动正常的P2模式，但在胚胎后期在前极异位表达。我们还报告了家蝇中驼背蛋白早期表达的差异。我们认为，在更高等双翅目不同大小胚胎中双胸蛋白形态发生功能的保守性需要双胸蛋白及其靶结合位点的共同进化。
