Levine J, Caspi N, Laufer N
Beersheba Mental Health Center, Faculty of Medicine, Ben Gurion University, Israel.
Schizophr Res. 1997 Jul 25;26(1):55-63. doi: 10.1016/S0920-9964(97)00034-0.
Reaction time and idiosyncrasy of word associations were examined in 30 schizophrenic patients, 2 h after administering a single dose of chlorpromazine, perphenazine or placebo. These patients were in the acute phase of their illness following 72 h cessation of oral neuroleptic treatment administered for 1-2 weeks. There was a statistically significant reduction in reaction times after administering perphenazine as compared to the placebo. Chlorpromazine showed some reduction in reaction times that was not statistically significant. Further study is needed to examine the relationship between such changes and other parameters, such as the patients' symptomatology and their social competence. Since many schizophrenic patients exhibit low or partial compliance, including patterns of intermittent taking of medication with a few days cessation, studies using such a model of a single dose of neuroleptic following several days withdrawal, may have clinical relevance. Another finding was a correlation between reaction time and the number of uncommon word associations produced. This correlation was beyond drug effect. Further study is needed to find out if such a correlation characterizes schizophrenic patients only.
在30例精神分裂症患者中，在单次服用氯丙嗪、奋乃静或安慰剂2小时后，检测其反应时间和词语联想的特质。这些患者处于疾病急性期，此前接受了1 - 2周的口服抗精神病药物治疗，且已停药72小时。与安慰剂相比，服用奋乃静后反应时间有统计学意义的显著缩短。氯丙嗪使反应时间有所缩短，但无统计学意义。需要进一步研究来考察此类变化与其他参数之间的关系，如患者的症状学表现及其社交能力。由于许多精神分裂症患者表现出低依从性或部分依从性，包括间歇性服药且停药数天的模式，采用停药数天后单次服用抗精神病药物的这种模型进行研究可能具有临床相关性。另一个发现是反应时间与产生的不常见词语联想数量之间存在相关性。这种相关性不受药物影响。需要进一步研究以确定这种相关性是否仅为精神分裂症患者所特有。
