Manukhin I B, Frank G A, Minkina G N, Simonova T V, Kulagina L A
Vestn Ross Akad Med Nauk. 1997(2):20-4.
The results of examinations of 35 patients aged 17 to 42 years who had abnormalities in the cervix uteri were analyzed. Colposcopy detected an atypical epithelium in 100% of cases. To verify the diagnosis, biopsy specimens from the cervix uteri were morphologically studied prior to and following treatment. Before treatment, there was a slight proliferative activity of the epithelium in 45% of cases and its high proliferative activity in 15% in uncomplicated papilloma viral infection (PVI). A follow-up of complicated PVI indicated increases in the expression of a proliferative nuclear antigen (PVA) with higher dysplasia: a moderate response in 75% of D3 + PVI cases and a higher response in 60% of preinvasive cancers. Analysis of PCNA-immunological reactivity of biopsy specimens taken after treatment estimates the efficiency of the chosen complex of treatments: there was a negative result of immunohistochemical responses.
对35名年龄在17至42岁之间子宫颈有异常的患者的检查结果进行了分析。阴道镜检查在100%的病例中检测到非典型上皮。为了核实诊断，在治疗前后对子宫颈活检标本进行了形态学研究。在未合并乳头瘤病毒感染（PVI）的情况下，治疗前45%的病例上皮有轻微增殖活性，15%有高增殖活性。对合并PVI的随访表明，随着发育异常程度加重，增殖细胞核抗原（PVA）表达增加：在75%的D3 + PVI病例中有中度反应，在60%的浸润前癌中有高度反应。对治疗后活检标本的PCNA免疫反应性分析评估了所选综合治疗的效果：免疫组化反应结果为阴性。
