Kuznetsov N S, Abulela A M, Kulagin Iu I, Neskromnyĭ V N, Babin Iu F
Lik Sprava. 1996 May-Jun(5-6):117-8.
Time course of changes was studied in parameters characterizing lipid peroxidation (LPO) and the total lipids counts in red cell membranes (RCM) and blood plasma (BP) of patients with hypertensive disease (HD) and arterial hypertension in chronic pyelonephritis against the background of diabetes mellitus (DM). The study groups were DM patients (group I), those with coexistent HDDM (group II), and those with arterial hypertension caused by chronic pyelonephritis in the presence of DM (group III). All three groups of patients demonstrated intensification of the cellular membrane- and blood plasma LPO as well as increase in the total lipids counts. HDDM results in much higher levels of the RCM and BP LPO products. Relatively higher RCM and BP LPO in group II patients as compared with III one, permits differentiating the above pathologic mixes. The results obtained allow us to recommend that antioxidants be incorporated into a complex therapy to be adopted for treating the above conditions.
研究了糖尿病（DM）背景下，高血压病（HD）患者及慢性肾盂肾炎合并动脉高血压患者红细胞膜（RCM）和血浆（BP）中表征脂质过氧化（LPO）的参数及总脂质含量随时间的变化情况。研究组包括糖尿病患者（I组）、同时患有高血压病和糖尿病的患者（II组），以及糖尿病合并慢性肾盂肾炎所致动脉高血压患者（III组）。所有三组患者均表现出细胞膜和血浆脂质过氧化加剧以及总脂质含量增加。高血压病合并糖尿病导致红细胞膜和血浆脂质过氧化产物水平更高。与III组患者相比，II组患者红细胞膜和血浆脂质过氧化水平相对较高，这有助于区分上述病理组合。所得结果使我们建议，抗氧化剂应纳入针对上述病症的综合治疗方案中。
